ELARA: POD24
Outcomes with tisa-cel in POD24 patients
Efficacy
PFS1
36-MONTH PFS IN POD24 PATIENTS
%
36-MONTH PFS in patients without POD24
%
OS1
36-MONTH PFS IN POD24 PATIENTS
%
36-MONTH PFS IN PATIENTS WITHOUT POD24
%
| CRR2 | |
|---|---|
| With POD24 | % |
| Without POD24 | % |
63% of patients in ELARA were POD241
36-month PFS and OS rates were consistent for patients with or without POD241
Outcomes with tisa-cel by age
Efficacy
CR1
ORR1
74% of patients in ELARA were under 65 years1
Median age: 57 (29−73)2
Tisa-cel induced consistently high response rates in patients aged <65 and ≥65 years1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
Outcomes with tisa-cel in patients with or without bulky disease
Efficacy
CR1
ORR1
64% of patients in ELARA had bulky disease2
Tisa-cel induced consistently high response rates in patients with or without bulky disease1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
Outcomes with tisa-cel in patients with or without high FLIPI
Efficacy
CR1
ORR1
60% of patients in ELARA had a high FLIPI score (≥3)2
Tisa-cel induced consistently high response rates in patients with or without high FLIPI scores1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
Outcomes with tisa-cel in patients by prior therapy
Efficacy
CR1
ORR1
Patients in ELARA had a median of 4 prior therapies2
Tisa-cel induced consistently high response rates in patients, irrespective of prior therapies1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
Outcomes with tisa-cel in patients who were double refractory
Efficacy
CR1
ORR1
68% of patients in ELARA were double refractory
to anti-CD20 mAb + alkylating agent2
Tisa-cel induced consistently high response rates even in patients who were double refractory1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
Outcomes with tisa-cel in patients with or without prior Auto SCT
Efficacy
CR1
ORR1
36% of patients in ELARA had previously
undergone autologous stem cell transplantation2
Tisa-cel induced consistently high response rates, even in patients who have relapsed post Auto SCT1
N=97 patients infused with tisa-cel. N=94 in efficacy analysis set.
Median follow-up: 41 months
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