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JULIET: Subgroup data

Median age

  years

(22-76)1,2

 %

were ≥65 years1

ORR

ORR in patients older or younger than 65 years
(40.3 months median follow-up)1

OS

OS in patients older or younger than 65 years
(19 months median follow-up)3

  • References: 1. Schuster SJ et al. Lancet Oncol 2021;22(10):1403–1415.
  • 2. Schuster SJ et al. N Engl J Med. 2019;380(1):45–56.
  • 3. Schuster SJ et al. Presented at ASH 2018.

 %

of patients in JULIET had double- or triple-hit rearrangement: MYC plus BCL2, BCL6, or both1

ORR

ORR in patients with or without double or triple-hit rearrangement (40.3 months median follow-up)1

  • Reference: 1. Schuster SJ et al. Lancet Oncol 2021;22(10):1403–1415.

 %

of patients in JULIET had been treated with 3 or more prior therapies1

ORR

ORR in patients treated with ≤2 and >2 prior lines (40.3 months median follow-up)1

  • Reference: 1. Schuster SJ et al. Lancet Oncol 2021;22(10):1403–1415.

 %

of patients in JULIET were refractory to their last therapy1

ORR

ORR in refractory and relapsed patients
(40.3 months median follow-up)1

OS

OS in refractory and relapsed patients
(19 months median follow-up)2

  • References: 1. Schuster SJ et al. Lancet Oncol 2021;22(10):1403–1415.
  • 2. Schuster SJ et al. Presented at ASH 2018.

9%

of patients in JULIET had received prior ASCT1

ORR in patients who had or had not received prior ASCT (40.3 months median follow-up)1

  • Reference: 1. Schuster SJ et al. Lancet Oncol 2021;22(10):1403–1415.

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